Progress of the susceptibility genetic research on asthma
10.3760/cma.j.issn.1673-4408.2015.02.001
- VernacularTitle:支气管哮喘相关基因的研究进展
- Author:
Shuang FENG
- Publication Type:Journal Article
- Keywords:
Asthma;
Genetics;
Susceptibility genes
- From:
International Journal of Pediatrics
2015;42(2):121-124
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is a complex polygenic disease,caused by environmental and genetic factors.Three key methods are used to identify asthma susceptibility genes,including positional cloning study,candidate gene study and the emerging trend of genome-wide association study.Chain analysis and correlation analysis are two main strategies.This review discusses the asthma susceptibility genes:TLR,IL-13,PDCD4,CCL-5,TRPV1,BDNF in the perspective of functional classification.
