Phosphoglycerate dehydrogenase and tumors
10.3760/cma.j.issn.1673-4408.2015.01.021
- VernacularTitle:磷酸甘油酸脱氢酶基因与肿瘤
- Author:
Shuiyan WU
- Publication Type:Journal Article
- Keywords:
Phosphoglycerate dehydrogenase;
Glycolysis;
Tumors
- From:
International Journal of Pediatrics
2015;42(1):70-72
- CountryChina
- Language:Chinese
-
Abstract:
Phosphoglycerate dehydrogenase (phosphoglycerate dehydrogenase,PHGDH) encodes 3-phosphoglycerate dehydrogenase,the first enzyme branching from glycolysis in the serine biosynthetic pathway.PHGDH uses NAD as a cofactor to oxidizes glycolytic intermediate,3-phosphoglycerate,into phosphor-hydroxypyruvate,which then convert into serine by a series of enzymes in the pathway.Serine is essential for synthesis of proteins and other biomolecules needed for cell proliferation,including nucleotides,phosphatidyl-serine,and sphingosine.Recent studies found that subsets of human malignant cancers have high levels of PHGDH,a key enzyme for serine biosynthesis,and these cancer cells are dependent on PHGDH for their growth and survival.In this paper we made a review on PHGDH gene about its construction,function and relation with tumors.
