The role of hyperpolarization-activated cyclic nucleotide-gated channels in learning and memory
10.3760/cma.j.issn.1673-4408.2015.01.015
- VernacularTitle:超极化激活的环核苷酸通道在学习与记忆中的作用
- Author:
Chun XU
- Publication Type:Journal Article
- Keywords:
HCN1 channel;
Learning;
Memory;
Synaptic plasticity;
Long-term facilitation
- From:
International Journal of Pediatrics
2015;42(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Hyperpolarization-activated cyclic nucleotide (HCN)-gated channels belong to a nonselective ion channel family,which are common in neurocyte and cardiac muscle cell.These channels play important roles in the nervous system because of their characterstics of hyperpolarization activation.Many studies have shown that HCN channels play key point in excitatory synaptic transmission and integration of output signal.With the development of research,more evidences have been found to prove that the motor learning is damaged and spatial learning ability is enhanced in HCN1 knockout mice.There are two potential mechanisms leading to these changes,one is the lack of HCN1 in cerebellum cell,and the other is the lack of HCN1 in trisynaptic circuits of hippocampus.
