Progress of mechanism of ω-3 polyunsaturated fatty acid in sepsis therapy
10.3760/cma.j.issn.1673-4408.2015.01.013
- VernacularTitle:ω-3多不饱和脂肪酸治疗脓毒症的机制研究进展
- Author:
Hongjun MIAO
- Publication Type:Journal Article
- Keywords:
Sepsis;
Immune nutrition;
Fish oil fat emulsion;
Omega-3 polyunsaturated fatty acid;
Inflammation;
Oxidative stress
- From:
International Journal of Pediatrics
2015;42(1):41-44
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation,immune suppression and oxidative stress is the main pathogenesis of sepsis.In recent years,more study have found ω-3 polyunsaturated fatty acid(ω-3PUFA) can inhibit inflammation by some mechanisms namely,reducing metabolites from arachidonic acid(AA) by competing with it through a variety of ways,alteration of membrane lipid rafts,inhibition of nuclear receptor activation(specifically nuclear factor NF-κB)to modulate production of inflammatory mediators,and metabolism into novel pro-resolving and antiinflammatory mediators (resolvins and protectins).In addition,ω-3PUFA can reduce oxidative stress by improvement the antioxidant defense system,etc.Many clinical studies have demonstrated that ω-3PUF is effective in the for sepsis patients.The paper reviews the specific mechanism of ω-3PUFA treatment for sepsis.
