Research progress on correlations between interlukin-28B polymorphism and hepatitis B
10.3760/cma.j.issn.1674-2397.2015.01.020
- VernacularTitle:白介素-28B基因多态性与乙型肝炎相关性研究进展
- Author:
Fei YE
;
Xiankai WANG
;
Yunqing QIU
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Interlukin-28B;
Gene polymorphism;
Interferons
- From:
Chinese Journal of Clinical Infectious Diseases
2015;8(1):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Interferon (IFN) is one of the commonly used anti-HBV drug in clinic,in which IFN-λ is a new type of IFN,including IFN-λ1,IFN-λ2 and IFN-λ3 (also called IL-29,IL-28A and IL-28B,respectively).Researches in recent years show that IFN-λ3 (IL-28B) polymorphism seems to be involved in the onset of hepatitis B,the response to antiviral therapy and the outcome of HBV infection.This paper reviews the correlations between IL-28B polymorphism and the spontaneous clearance of HBV,the progression of HBV infection,the occurrence of liver cancer and the therapeutic effect of IFN treatment.
