Clinical relevance of anti-CCP antibody in the clinical testing
10.3760/cma.j.issn.1009-9158.2014.12.008
- VernacularTitle:抗环瓜氨酸肽抗体用于类风湿关节炎临床检测的价值
- Author:
Yulong LI
;
Rui ZHANG
;
Jinming LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Peptides,cyclic;
Rheumatoid factor
- From:
Chinese Journal of Laboratory Medicine
2014;37(12):903-906
- CountryChina
- Language:Chinese
-
Abstract:
As a kind of common autoimmune diseases,rheumatoid arthritis (RA) affected the health of human beings seriously.In the past,serological diagnosis of RA solely relied on the detection of rheumatoid factor (RF),but its specificity was not satisfactory.Lately,people found that anti-cyclic citrullinated peptide (CCP) antibody was a serological indicator of RA.Now,there have been a series of kits for the detection of anti-CCP antibodies to diagnose RA.The sensitivity and specificity of anti-CCP antibody detection are better than those of RF detection.This paper reviews the significance and value of anti-CCP antibody detection used for clinical diagnosis in the recent years,while systematically compares the sensitivities and specificities between several common commercial kits and methods of anti-CCP antibodies detection.
