The current development of heme oxygenase-1 and its correlation with macrophage infiltration in adipose tissue of obese individuals
10.3760/cma.j.issn.1673-4408.2015.01.007
- VernacularTitle:肥胖个体血红素加氧酶-1与脂肪中巨噬细胞浸润相关性的研究进展
- Author:
Tingting LIU
- Publication Type:Journal Article
- Keywords:
Obesity;
Heme oxygenase-1;
Inflammation;
Macrophage infiltration
- From:
International Journal of Pediatrics
2015;42(1):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is mostly recognized as a chronic inflammatory condition in which the balance of normal state is destroyed and it is a risk of cardiovascular disease and many other chronic metabolic disease.Heme oxygenase-1 (HO-1),a major cytoprotective enzyme,exerts significant antioxidant and anti-inflammatory effects.It also can improve the function of fat cells and enhanced insulin sensitivity in obese individuals.The researches of HO-1 for the anti-inflammatory effects and its intervention have great significance in improving the inflammatory state and its related diseases in obesity.This paper elaborates the change of HO-1 and its effect for macrophage infiltration in obesity.
