Effect of losartan combined with atorvastatin in treatment of essential hypertension and its influence on the plasma high sensitive C reactive protein, endothelial factors, and levels of nitric oxide
10.3760/cma.j.issn.1008-6706.2015.01.029
- VernacularTitle:氯沙坦联合阿托伐他汀治疗原发性高血压的疗效及对血浆高敏C反应蛋白、内皮素和一氧化氮水平的影响
- Author:
Bo ZHOU
;
Liang ZHU
;
Hongzhen LIU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Ato Vatatin;
Losartan
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(1):86-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of losartan combined with atorvastatin in the treatment of essential hypertension and its influence on the plasma high sensitive C reactive protein(hs-CRP),endothelin (ET) and the level of nitric oxide(NO).Methods According to the digital table,84 patients with primary hypertension were randomly divided into the two groups of 42 cases,the control group was given losartan for treatment,the observation group was treated with losartan combined with atorvastatin.The clinical curative effect and the changes of plasma hs-CRP,ET and the level of NO before and after treatment were compared between the two groups.Results The effective rate of the observation group was 92.86％,which was significantly higher than 80.95％ of the control group(x2 =7.85,P ＜ 0.05);The levels of plasma hs-CRP and ET of the observation group after treatment were (3.02 ± 0.29) mg/L and (34.44 ± 4.59) μg/L,which were significantly lower than (5.30 ± 0.38) mg/L and (58.30 ± 5.27) μg/L of pretreatment and (4.95 ± 0.36) mg/L and (55.93 ± 5.71) μg/L of the control group (t =7.43,8.10,7.89,8.56,all P ＜ 0.05);The NO level of the observation group after treatment was (70.47 ± 4.58)μmol/L,which were significantly higher than (44.43 ± 3.41)μ mol/L of pretreatment and (46.33 ± 3.81) μmol/L of the control group(t =8.69,9.04,all P＜0.05).Conclusion Atorvastatin combined with losartan has a definite effect in treatment of primary hypertension,which can significantly improve the inflammation and endothelial function of patients that has a good clinical application value.
