Progress of E.coli producing extended spectrum beta-lactameses in children with urinary tract infection
10.3760/cma.j.issn.1673-4408.2015.01.005
- VernacularTitle:尿路感染患儿产ESBL大肠埃希菌的研究进展
- Author:
Lingzhi WANG
- Publication Type:Journal Article
- Keywords:
Extended spectrum Beta-lactamases;
Escherichia coli;
Urinary tract infection
- From:
International Journal of Pediatrics
2015;42(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Urinary tract infections (UTI)is a childhood disease.With the use of extended spectrum antibiotics,resistant strains have increased every year,especially Escherichia coli(E.coli).The mechanisms of drug resistance are as follows:hydrolase,target gene mutations,efflux pumps and membrane permeability change.Of which producing extended-spectrum β-lactamase(ESBL) is increasing.So it presents a huge challenge to clinical antibiotic selection.According to the resistance genes (blaTEM,blaSHV,blaCTX-M,etc.),the ESBL can be classified into different types (TEM type,SHV-type,CTX-M type,etc.).The drug-resistant genes play an important role in spreading and prevalence of the resistance genes.It's necessary to do a review of the currently known genotypes.It is both in favor of scientific research work and providing guidance for clinical work.
