Assessment for early embryo quality improves the sensitivity and specificity to predicting embryonic development potential
10.3969/j.issn.2095-4344.2014.42.024
- VernacularTitle:早期胚胎质量评估：提高预测胚胎发育潜能的敏感性和特异性
- Author:
Nan LI
;
Jingyu LI
;
Yongmei TANG
;
Jihong WEI
- Publication Type:Journal Article
- Keywords:
reproductive techniques,assisted;
embryonic development;
technology assessment,biomedical
- From:
Chinese Journal of Tissue Engineering Research
2014;(42):6849-6855
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Embryo viability assessment is directly related to the selection of embryo transplantation and clinical outcome of assisted reproduction.
OBJECTIVE:To summarize the assessment methods for early embryonic development.
METHODS:The first author searched PubMed database for relevant articles published from January 1990 to
December 2013 using the keywords of“assisted reproductive technology, art;pre-implantation embryo;embryonic development viability;evaluation methods”in English. Final y, 63 articles were included in result analysis.
RESULTS AND CONCLUSION:In the embryo quality evaluation, the most widely used method is morphological evaluation method which is characterized as rapid, non-invasive, and simple. With the development of assisted reproductive technology, the morphological evaluation combined with time-lapse imaging analysis system has been recognized in embryo selection. Recently, targeted-metabolic analysis has been proposed as a useful tool for assessment of embryo development potential, involving pyruvate acid, glycometabolism, amino acid, and embryo-derived cytokines (soluble human leukocyte antigen G1, platelet-activating factor, etc.). Furthermore, the pre-implantation genetic screening method targeting gene and chromosome abnormality is expected to find more effective markers for evaluating embryo developmental potential.
