Role of human umbilical cord mesenchymal stem cells:cell transplantation, immuoregulation and target cells
10.3969/j.issn.2095-4344.2014.41.027
- VernacularTitle:人脐带间充质干细胞的作用：细胞移植、免疫调节及充当基因治疗靶细胞
- Author:
Guangping RUAN
;
Xiang YAO
;
Jufen LIU
;
Fan SHU
;
Jie HE
;
Jianyong YANG
;
Rongqing PANG
;
Xinghua PAN
- Publication Type:Journal Article
- Keywords:
umbilical cord;
mesenchymal stem cells;
disease models,animal;
review
- From:
Chinese Journal of Tissue Engineering Research
2014;(41):6714-6718
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Umbilical cord as childbirth waste has wide variety of sources and can be easily obtained, without any ethical and legal restrictions. Therefore, human umbilical cord mesenchymal stem cells break al the restrictions originated from other sources of mesenchymal stem cells. OBJECTIVE:To review the application of human umbilical cord mesenchymal stem cells in cartilage diseases, neuroglioma, ischemic brain injury, lung disease, liver disease and models of myocardial infarction. METHODS:The PubMed and Wanfang databases were searched by the first author using the keywords of“human umbilical cord mesenchymal stem cells, disease models, celltherapy”in English and Chinese, respectively. Seventy-three articles were searched and final y, 35 articles were included in result analysis. RESULTS AND CONCLUSION:Human umbilical cord mesenchymal stem cells have multilineage differentiation capacity similar to bone marrow mesenchymal stem cells. Compared with bone marrow mesenchymal stem cells, human umbilical cord mesenchymal stem cells have lower immunogenicity. Human umbilical cord mesenchymal stem cells show certain curative effects on cartilage disease, neuroglioma, ischemic brain injury, lung disease, liver disease and myocardial infarction, indicating that human umbilical cord mesenchymal stem cells can be used for celltransplantation to treat various diseases.
