Clinical investigation on relationship among lipoprotein(a) ,cerebral infarction and carotid atherosclerosis
10.3760/cma.j.issn.1008-6706.2015.01.016
- VernacularTitle:血清脂蛋白a水平与脑梗死及颈动脉粥样硬化关系的临床研究
- Author:
Bin SHEN
;
Chuan YU
;
Dongyu WANG
- Publication Type:Journal Article
- Keywords:
Lipoprotein (a);
Cerebral infarction;
Carotid artery diseases;
Atherosclerosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(1):48-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation among Lp (a),cerebral infarction and carotid atherosclerosis.Methods 180 cases were equally divided into 3 groups (60 cases in each group).The patients with both cerebral infarction and carotid atherosclerosis composed one group(cerebral infarction group for short) ;the patients of carotid atherosclerosis which without cerebral infarction composed another group(no cerebral infarction group for short) ;the control group composed with those who had neither cerebral infarction nor carotid atherosclerosis.The level,outlier detection rate about Lp(a) and usual risk factors of cerebral infarction were compared in this research.Results The level and detection rate of Lp(a) in the cerebral infarction group were (512 ± 156) mg/L and 46.7％ ;the level and detection rate of Lp(a) in the no cerebral infarction group were (316 ± 87)mg/L and 20.0％ ;the level and detection rate of Lp(a) in the control group were (199 ± 123) mg/L and 5.0％.The differences of the level and outlier detection rate of Lp(a) among the three group were significant(F=13.87,x2 =29.394,P ＜0.01).Cerebral infarction patients had more usual risk factors of cerebral infarction (hypertension,diabetes,hyperlipemia,drinking,smoking,obesity and lack of exercise) than those who without cerebral infarction (x2 =15.523,P ＜ 0.01).Conclusion The abnormal of Lp(a) was an important risk factor of cerebral infarction.The general survey of Lp(a) was significant in the primary and secondary prevention of stroke.To the people whose assay of Lp(a) was abnormal,the control of governable risk factors of cerebral infarction should actively be carried out.
