Research advances in molecular mechanism of pharmacological actions of oxymatrine
10.3969/j.issn.1001-1978.2015.06.005
- VernacularTitle:氧化苦参碱药理作用的分子机制研究进展
- Author:
Qin WU
;
Yun GAO
- Publication Type:Journal Article
- Keywords:
oxymatrine;
pharmacologic actions;
molecular mechanism;
inflammatory factor;
cell apoptosis;
anti-fibrosis
- From:
Chinese Pharmacological Bulletin
2015;(6):759-762
- CountryChina
- Language:Chinese
-
Abstract:
Oxymatrine is the main effective monomer of Radix Sophorae flavescentis( Kushen) , which has a variety of pharma-cological actions and valuable clinical applications. Recently, there are many reports about molecular mechanisms of oxymatrine pharmacological actions, giving highly attention to the anti-in-flammatory, anti-fibrosis and antineoplastic effects. These effects are achieved through resisting of oxidation and free radical, anti- ＜br> virus, and affecting the secretion of inflammatory factor and ap-optosis and so on. This article summarizes the reports on the mo-lecular mechanism of the protection on liver, cardiovascular sys-tem, endocrine system and nervous system, hoping to provide theoretical basis for the practical application.
