Research progress of double-hit diffuse large B-cell lymphoma

VernacularTitle:伴有二次打击的弥漫大B细胞淋巴瘤研究进展
Author: Fan ZHANG
Publication Type:Journal Article
Keywords: Double-hit lymphoma; Lymphoma,large-cell,diffuse; Genes,myc; Genes,bcl-2; Genes,bcl-6
From: Journal of Leukemia & Lymphoma 2014;23(2):120-123
CountryChina
Language:Chinese
Abstract: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of non-Hodgkin's lymphoma.An uncommon subset with myc and either bcl-2 or bcl-6 rearrangement,also known as ‘double-hit’ lymphomas,is considered very aggressive clinical course and poor prognosis despite high-intensity chemotherapy.Recently,these lymphomas have received increased attention.This review explores the existing literatures for the involved genes with their functions,clinical features,diagnosis and treatment.