Dynamin-related protein 1-mediated mitochondrial fission and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2015.04.014
- VernacularTitle:发动蛋白相关蛋白1介导的线粒体分裂与脑缺血
- Author:
Zhiwei LU
;
Xinyong ZHU
;
En XU
- Publication Type:Journal Article
- Keywords:
Dynamins;
Mitochondria;
Reactive Oxygen Species;
Brain Ischemia
- From:
International Journal of Cerebrovascular Diseases
2015;23(4):306-310
- CountryChina
- Language:Chinese
-
Abstract:
Dynamin-related protein 1 (Drpl) is a major protein for regulating mitochondrial fission.Its activity is associated with the post-translational modification,mainly including phosphorylation,ubiquitination,sumoylation,and S-nitrosylation.During the cerebral ischemia,Drpl is activated and translocates from the cytoplasm to the mitochondrial outer membrane,mediates mitochondrial fission and eliminates damaged mitochondria.Drpl plays the important roles in the pathological processes of ischemic neuronal apoptosis,necrotic apoptosis,and mitophagy.Excessive mitochondria fission or accumulation of damaged mitochondria will aggravate neuronal injury.
