Application prospect of carbon nanotubes for the treatment of cerebral ischemia with mesenchymal stem cells
10.3760/cma.j.issn.1673-4165.2014.12.013
- VernacularTitle:碳纳米管在间充质干细胞治疗脑缺血中的应用前景
- Author:
Tan LI
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Brain Ischemia;
Mesenchymal Stromal Cells;
Nanotubes,Carbon
- From:
International Journal of Cerebrovascular Diseases
2014;22(12):950-953
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSCs) play a neuroproteetive effect via a variety of mechanisms.They provide a new idea for the treatment of cerebral ischemia.However,the inadequate sources have significantly limited the possible clinical applications.Carbon nanotubes (CNTs),a new nanomaterials,can not only promote the adhesion,proliferation and differentiation of MSCs in vitro,but also as the cell carriers they can provide good microenvironmental guarantee for the survival of MSCs through the regulation of secretion of cytokines and neurotrophic factors,as well as regulation of biological characteristics of neurons,glial cells,and macrophages after their cell transplantation,provide a good microenvironment guarantee for the survival of MSCs,and promote the effect of MSCs on the therapeutic effect of cerebral ischemia.
