The significance of serum neutrophil extracellular traps in rheumatoid arthritis
10.3760/cma.j.issn.1007-7480.2015.02.012
- VernacularTitle:类风湿关节炎患者血清中性粒细胞胞外诱捕网水平的检测及其意义
- Author:
Benlu CHEN
;
Long QIAN
;
Xiangpei LI
;
Xiaomei LI
;
Guosheng WANG
;
Jinhui TAO
;
Yue TAN
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Neutrophil extracellular traps
- From:
Chinese Journal of Rheumatology
2015;19(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of serum neutrophil extracellular traps (NETs) in rheumatoid arthritis (RA).Methods The serum circulating free DNA (cf-DNA) / NETs in 45 RA patients and 18 healthy controls were detected by Pico Green dsDNA Quantitation Kits,and the association between serum NETs and ESR,DAS28 score,anti-CCP antibodies was analyzed.T test,rank sum test,Pearson or Spearman correlation analysis were ued for statistical analysis.Results ① The levels of serum dsDNA/NETs in RA patients [0.523 0(0.282 0,1.637 0) μg/ml] were significantly higher than those in healthy controls [0.410 5 (0.140 0,0.966 0)μg/ml] (Z=-2.419,P=0.016).② The level of serum dsDNA/NETs in RA was positively correlated with ESR and DAS28 score (r=0.357,P=0.016; r=0.325,P=0.029),but not with anti-CCP antibodies(r=0.146,P=0.434).③ The levels of serum dsDNA/NETs in RA treated by DMARDs were lower than those of untreated with DMARDs[0.516 5(0.282 0,1.637 0) μg/ml,0.523 0 (0.369 0,1.485 0) μg/ml,Z=-1.215,P=0.225],but the difference was not significant.Conclusion NETs maybe associated with disease activity and play an important role in RA pathogenesis.
