The effects of sustained +Gz condition and administration of depside salt from salvia miltiorrhiza on the dental pulp of rats
10.3969/j.issn.1001-3733.2014.06.02
- VernacularTitle:丹参多酚酸盐对持续性＋Gz 环境下大鼠牙髓的影响
- Author:
Yin YIN
;
Xin CHEN
;
Dongxia LI
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
+Gz;
Rats;
Pulp;
Heat shock protein(HSP70);
Depside salt from salvia miltiorrhiza(DSSM)
- From:
Journal of Practical Stomatology
2014;(6):748-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate effects of depside salt from salvia miltiorrhiza(DSSM)on the dental pulp of rats under repeated exposure to +Gz acceleration.Methods:27 male SD rats were randomly divided into 9 groups(n =3).The rats in negative control group was only fixed with rats kept-keeling device,in positive control group were exposed to +5 Gz and +10 Gz respectively for 30 s each time,5 times per day,4 days per week,for 3 consecutive weeks.The rats in other groups were respectively given DSSMat 2,6 and 18 mg/kg respectively 30 min before each +Gz exposure.The rats in negative and positive control groups were injected with 0.9%sodium chloride solution 30 min prior to +Gz exposure.After the experiment,The pulp changes were observed by HE staining.Real time qPCR was applied to determine the relative expression of heat sheck protein(HSP70)mRNA.Results:+Gz exposure decreased the activity degree of the rats,and resulted in damage of rat dental pulp.With the increase of +Gz value,the relative expression of HSP70 mRNA was increased(P ＜0.05).HSP70 mRNA expression in drug groups was less than that in their own positive control groups,but showed statistical significance only in the 18 mg/kg and +10 Gz group(P ＜0.05).Conclusion:+Gz exposure may dam-age dental pulp.DSSMhas certain protective effect under +Gz exposure.
