The effects of A-NK cells on tumor growth of human tongue squamous cell carcinoma in nude mice
10.3969/j.issn.1001-3733.2014.06.03
- VernacularTitle:A-NK 细胞对舌鳞癌裸鼠皮下移植瘤抑制作用的实验研究
- Author:
Jun ZHU
;
Hong LIU
;
Zhen ZHANG
;
Xiaojie DIAO
- Publication Type:Journal Article
- Keywords:
A-NK cells;
Tongue squamous cell carcinoma;
Nude mice model;
Anti-tumor effect
- From:
Journal of Practical Stomatology
2014;(6):753-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the treatment effect of A-NK cells on the subcutaneously transplanted tumor of tongue squamous cell carcinoma in nude mice.Methods:Tca8113-Tb cells were subcutaneously transplanted into nude mice,14 tumor bearing mice were randomly assigned to 2 groups(n =7).The mice in control group were injected with normal saline,those in the experimental group were injected with A-NK cells.All animals were killed 33 days after tumor cell transplantation,The tumor volume and weight of the mice were measured and compared.Results:A-NK cells significantly inhibited tumor growth in nude mice in terms of the volume (P ＜0.05).After 15 -33 d of treatment the tumor weight(g)in the treated and control mice were 0.96 ±0.38 and 3.74 ±1.22 re-spectively(P ＜0.05).Conclusion:A-NK cells can inhibit the growth of Tca8113-Tb cell induced tumor in nude mice.
