Circadian rhythm changes of PGE2 levels in blood of growing rats after functional mandibular protrusion

VernacularTitle:功能矫治大鼠前伸下颌后血中 PGE2的节律变化
Author: Ya LI ; Yanping ZUO ; Xiao JI ; Ji ZOU
Publication Type:Journal Article
Keywords: Functional appliance; Mandibular advancement; Condylar reconstruction; Prostaglandin
From: Journal of Practical Stomatology 2014;(6):757-759
CountryChina
Language:Chinese
Abstract: Objective:To explore the relationship between wearing of functional appliance and systemic metabolism of PGE2 in the blood of growing rats.Methods:54 male Wistar rats aged 4-weeks were randomly divided into 3 groups(n =18):Daytime group,all-day group and control group.Self-guided functional appliance was made for mandible advancement of the rats in the 2 experimental groups.One week after appliance wearing,rats were sacrificed at the corresponding time points and blood in femoral artery was taken. PGE2 levels in the blood samples were measured,data were analysed by cosine equation.Results:Hypothesis was true in the control group(P ＜0.05),and was not true in both 2 experimental groups(P >0.05).Conclusion:PGE2 level in rat blood is circadian rhyth-mic,wearing of functional appliance made may disturb the rhythm.