Correlation of LAIR-1 and TGF-βexpression in the peripheral blood of OLP patients

VernacularTitle:LAIR-1与 TGF-β在口腔扁平苔藓患者外周血中表达的相关性研究
Author: Lihui ZHANG ; Yanjun LI ; Ping YU ; Aili FU ; Jiangnan XUE ; Yusan LIU
Publication Type:Journal Article
Keywords: Oral lichen planus(OLP); Treg; LAIR-1; TGF-β; Flow cytometry; ELISA
From: Journal of Practical Stomatology 2014;(6):760-763
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of LAIR-1 on Treg cells and TGF-βin the peripheral blood of patients with oral lichen planus(OLP).Methods:The peripheral blood was obtained from 22 OLP patients and 22 healthy controls.Flow cytometry was used to evaluate the proportion of LAIR-1 on CD4 +Foxp3 +Treg cells,and the level of TGF-βwas measured by ELISA.Results:In the peripheral blood of OLP patients,the proportion of LAIR-1 on CD4 +Foxp3 +Treg cells and TGF-βcontent were significantly higher than those of the healthy controls(P ＜0.05),The proportion of LAIR-1 on CD4 +Foxp3 +Treg cells was positively correlated with the level of TGF-β(r =0.43,P ＜0.05).Conclusion:The high expression of LAIR-1 on CD4 +Foxp3 +Treg cells and TGF-βin the pe-ripheral blood of OLP patients may be responsible for the pathogenesis of OLP.