The Differential Expression of MMP-9 and Ki67 in Pancreatic Cancer
10.3969/j.issn.0253-9896.2014.01.014
- VernacularTitle:MMP-9和Ki67在胰腺癌中表达的意义
- Author:
Yu SUN
;
Ning SUN
;
Shaoshi YANG
;
Guodong SONG
;
Jianqiu CHEN
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
MMP-9;
Ki67;
immunohistochemistry;
prognosis
- From:
Tianjin Medical Journal
2014;(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of MMP-9 and Ki67 for predicting the progres-sion and prognosis of pancreatic cancer. Methods S-P immunohistochemical method was used to detect the expressions of MMP-9 and Ki67 in 100 pancreatic cancer tissue specimens. The relationship between the expressions of MMP-9 and Ki67 and patient age, tumor size, lymph node metastasis, tumor differentiation, clinical stages and prognosis were analyzed. Re-sults There were higher expressions of MMP-9 protein 46%(46/100) and Ki67 protein 53%(53/100) in 100 samples of pancreatic adenocarcinoma. And the expressions of MMP-9 and Ki67 were inversely associated with tumor differentiation, clinical stages, and lymph node metastasis of pancreatic cancer (P＜0.05). There were no significant differences in the ex-pressions of MMP-9 and Ki67 between patient age and tumor size. The expressions of MMP-9 and Ki67 were positive corre-lated (rs=0.405,P＜0.05). Moreover, the overall survival rates were correlated with patient age, lymph node metastasis, tumor differentiation and the expression of MMP-9, but no correlation with tumor size, clinical stages, and the expression of Ki67. Conclusion The expressions of MMP-9 and Ki67 were associated with pancreatic cancer progression. And the detection of expression of MMP-9 may have practical value in prognosis in patients with pancreatic cancer.
