Clinic study of serum product advanced oxidation protein changes of patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6315.2014.11.020
- VernacularTitle:慢性阻塞性肺疾病患者血清晚期氧化蛋白产物水平变化的临床研究
- Author:
Jilong SHEN
;
Hongjun GU
;
Xiaohong PEI
;
Qingtai ZHOU
;
Ling LI
;
Xuemei ZHOU
;
Xiaoxuan ZHU
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Advanced oxidation protein products;
Superoxide dismutase;
Malondialdehyde
- From:
Clinical Medicine of China
2014;30(11):1184-1187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of advanced oxidation protein products (AOPP) in patients with chronic obstructive pulmonary disease (COPD) as well as explore the relevance of its clinical significance AOPP and COPD.Methods Fifty-four patients with mild/moderate COPD (COPD group) were enrolled in this study,who were treated in the No.100th Hospital of the Chinese People's Liberation Army from Apr.2011 to Nov.2013.Thirty healthy volunteers (control group) at same period were selected as control group and the general condition of two groups were matched.AOPP,superoxide dismutase(SOD) and malondialdehyde (MDA) levels were measured.Results The serum AOPP,MDA and SOD in control group were (45.78 ± 12.54) μmol/L,(2.96 ± 0.55) μmol/L and (78.40 ± 8.37) kU/L respectively.And its were (68.93 ± 10.62) μmol/L,(6.07 ± 2.44) μmol/L and (53.66 ± 5.99) kU/L respectively in COPD group.The differences were statistically significant (t =-8.57,-9.14,14.38 ; All P values were less than 0.01).The serum AOPP,MDA and SOD in mild COPD group were (65.56 ±9.65) μmol/L,(4.21 ± 1.83) μmol/L and (62.97 ± 6.28) kU/L respectively,and (71.79 ± 11.37) μmol/L,(7.43 ± 3.12) μmol/L and (41.25 ± 5.89) kU/L respectively in moderate CODP group.The differences were statistically significant (t =-2.17,-4.80,13.00; P ＜ 0.05 or P ＜ 0.01).Conclusion The increased levels of serum AOPP is important pathological changes in patients with COPD,which may be involved in the occurrence and development of COPD,and is the reaction of oxidative stress injury in patients with COPD early sensitive indicator.
