PhoP-PhoR two-component signal transduction systems in pathogenesis of Mycobacterium tuberculosis
10.3969/cjz.j.issn.1002-2694.2014.10.016
- VernacularTitle:PhoPR双组份系统在结核分枝杆菌致病机制中的研究进展
- Author:
Bo WU
;
Wanjiang ZHANG
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
PhoPR TCS;
pathogenesis
- From:
Chinese Journal of Zoonoses
2014;(10):1062-1065
- CountryChina
- Language:Chinese
-
Abstract:
Two-component signal transduction system (TCS) exists extensively in prokaryotic cell ,which plays a key role of regulation in the growth ,differentiation ,metabolism ,virulence ,persistence ,and pathogenicity .PhoPR two-component signal transduction system ,as one of two-component systems ,is the most basic and the most importantly sensitive to the envi-ronmental changes and makes corresponding certain reaction system adapt to changes in the host microenvironment .Therefore , PhoPR TCS which is an important regulatory system of Mycobacterium tuberculosis (MTB) to adapt to environmental change has been increasing concern ,even PhoPR TCS is becoming the new front-burner issue in the pathogenesis of M TB regulation of research .
