Clinical significance of IL-17 in peripheral blood of patients with rheumatoid ar-thritis
10.3969/j.issn.1000-484X.2014.10.023
- VernacularTitle:IL-17在类风湿关节炎患者外周血表达的临床意义
- Author:
Changyan CHE
;
Guohua ZHANG
;
Junping LIU
;
Mingliang WANG
- Publication Type:Journal Article
- Keywords:
Interleukin-17;
Rheumatoid arthritis;
Clinical significance
- From:
Chinese Journal of Immunology
2014;(10):1405-1407
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role and significance of IL-17 on the pathogenesis of rheumatoid arthritis ( RA).Methods:The levels of IL-17 mRNA in peripheral blood mononuclear cell ( PBMC) of 66 RA patients (32 active,34 inactive) and 44 healthy controls were detected by reverse transcription-polymerase chain reaction ( RT-PCR ).The levels of serum IL-17 were detected by enzyme-linked immunosorbent assay ( ELISA).The levels of RF were detected by immunoturbidimetric assay.The correlations of serum IL-17 and RF were analyzed.Results: In RA patients the levels of IL-17 mRNA in PBMC were significantly higher than those in healthy controls ( P＜0.05 ) , but there was no difference between the active and inactive RA ( P>0.05 ).The serum IL-17 levels in active RA patients were significantly higher than those in inactive RA patients and healthy controls ( P＜0.05 ).The levels of serum IL-17 were positively correlated with RF in RA patients.Conclusion: IL-17 and RF play an important role in the pathogenesis and pathology process of RA ,and IL-17 may be associated with RA activity.
