Selective serotonin reuptake inhibitors for the treatment of ischemic stroke
10.3760/cma.j.issn.1673-4165.2014.08.009
- VernacularTitle:选择性5-羟色胺再摄取抑制药治疗缺血性卒中
- Author:
Yan YANG
;
Yi GUO
- Publication Type:Journal Article
- Keywords:
Serotonin Uptake Inhibitors;
Stroke;
Brain Ischemia;
Neurogenesis;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2014;22(8):625-628
- CountryChina
- Language:Chinese
-
Abstract:
Selective serotonin reuptake inhibitors (SSRIs),a new generation of anti-depressant agent,are mainly used to treat emotional disorders in clinical practice now.Recent studies have found that SSRIs can increase neurogenesis after cerebral ischemia,promote neurovascular reconstruction,and are conducive to the recovery of neurological function.Furthermore,SSRIs can improve the tolerance of ischemic tissue,exert anti-inflammation and anti-oxidation properties,reduce the blood-brain-barrier injury,and inhibit excitatory amino acid toxicity in order to exert neuroprotective effect.This article reviews the related research progress in SSRIs and ischemic stroke.
