Evaluation of antithrombotic efficacy and safety for tirofiban in treatment of senile non-ST-elevation acute coronary syndrome
10.3760/cma.j.issn.1673-4904.2014.34.020
- VernacularTitle:非ST段抬高型急性冠状动脉综合征高龄患者应用替罗非班强化抗栓治疗的临床评价
- Author:
Yi LI
;
Yanlin FENG
;
Huaisheng BAI
;
Rui MA
- Publication Type:Journal Article
- Keywords:
Aged;
Acute coronary syndrome;
Safety;
Tirofiban
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(34):60-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of radical antithrombotic therapy(aspirin,clopidogrel and tirofiban) in the treatment of senile (≥ 75 years) non-ST-elevation acute coronary syndrome (NSTEACS).Methods A total of 146 senile patients with NSTEACS were divided into observation group (70 cases) and control group(76 cases) by random digits table method.The control group was given aspirin,low molecular weight heparin and clopidogrel,and the observation group was added tirofiban (intravenous loading dosage:0.4 μ g/ (kg· min) for 30 min and then maintaining 0.1 μ g/ (kg· min) for 48-72 h).The occurrence of major adverse cardiovascular events (MACE) within 30 d after treatment,7 d angina pectoris control rate and adverse reactions were observed in two groups.Results The occurrence rate of MACE within 30 d after treatment was 5.7％ (4/70) in observation group,and 14.5％ (11/76) in control group,and there was significant difference (P ＜ 0.05).The 7 d angina pectoris control rate was 92.9％ (65/70) and 76.3 ％ (58/76) in observation group and control group,and there was significant difference (P ＜ 0.05).The incidence of bleeding was 10.0 ％ (7/70) and 7.9 ％ (6/76) in observation group and control group,and there was no significant difference (P ＞ 0.05).There were no major bleeding events in two groups.One case had thrombocytopenia in observation group,but there was no significant difference compared with that in control group(P ＞ 0.05).Conclusion Triofiban on the basis of aspirin and clopidogrel in the treatment of senile NSTEACS is effective and safe.
