Prevention of Allograft Rejection by Immune Tolerance.
- Author:
Jong Soo LEE
1
;
Byungsuk KWON
;
Hong Rae CHO
Author Information
1. Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Korea.
- Publication Type:Review
- Keywords:
Transplantation tolerance;
Mixed hematopoietic chimerism;
Costimulatory blockade;
Regulatory T cells
- MeSH:
Allografts*;
Chimerism;
Graft Survival;
Immune Tolerance*;
Immunosuppressive Agents;
T-Lymphocytes, Regulatory;
Transplantation Tolerance
- From:The Journal of the Korean Society for Transplantation
2006;20(1):1-13
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The development of immunosuprressants has had a significant contribution to inhibition of acute allograft rejection. However, long-term graft survival has not been realized by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune tolerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using three different approaches; mixed hematopoietic chimerism, costimulatory blockade, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection.
