Effect of different chemotherapy regimens on bone marrow suppression and immune of patient with advanced non small cell lung cancer
10.3760/cma.j.issn.1008-6315.2014.10.022
- VernacularTitle:两种不同化疗方案对晚期非小细胞肺癌患者骨髓抑制及免疫力的影响
- Author:
Shuying WAN
- Publication Type:Journal Article
- Keywords:
Non small cell lung cancer;
NP chemotherapy;
DP chemotherapy;
Bone marrow suppression;
Immunity
- From:
Clinical Medicine of China
2014;30(10):1069-1071
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the different chemotherapy regimens on bone marrow inhibition and immunity of patients with advanced non small cell lung cancer.Methods Forty-six patients with advanced non-small cell lung cancer were randomly divided into NP group (Changchun vinorelbine plus cisplatin,n =23) and DP group(docetaxel,cisplatin,n =23).The bone marrow suppression and immune function were analyzed before chemotherapy and after 2 cycles chemotherapy.Results The median survival time(MST) in NP group and DP group were 10.3 months and 6.2 months respectively (x2 =2.987,P ＜ 0.005),and 1-year survival rates were 52.17％ and 30.43％ respectively (x2 =2.693,P ＜ 0.005).After chemotherapy,blood platelet number in DP group was (108.87 ± 15.63) x 109/L,lower than that in NP group ((128.17 ± 15.3) x 109/L,t =3.819,P ＜ 0.05).CD3 +,CD4 +,CD8 +,CD4 +/CD8 + and NK cell rate in NP group before chemotherapy were (61.17 ±9.13)％,(36.99±7.83)％,(26.94 ±6.14)％,(1.93 ±0.21)％,(30.12 ±8.62)％ respectively,and (52.82 ±8.19)％,(33.22 ±6.92)％,(23.21 ±5.64)％,(1.53 ±0.11)％,(28.07 ± 8.17)％ after chemotherapy.There were significantly lower than that before chemotherapy significant (t =2.097,3.217,2.251,3.027,2.717;P ＜0.05).CD3+,CD4+,CD8+,CD4+/CD+ 8 and NK in DP group before chemotherapy were (62.82 ±9.13)％,(38.82 ±9.19)％,(27.81 ±7.97)％,(1.82 ±0.13)％,(31.82 ±7.48)％ respectively,higher than that after chemotherapy ((50.76 ±8.19)％,(28.92 ±8.13)％,(20.82±8.93)％,(1.36±0.16)％,(29.12±7.31)％; t =2.347,2.591,3.857,2.438,2.157; P＜ 0.05).Compared with the DP group,CD4 +,CD8 +,CD4 +/CD8 + in NP patients increased significantly (t =2.591,3.785,2.438 ; P ＜ 0.05).CD3 +,NK in two groups were not statistically significant (t =0.027,0.323 ;P ＞ 0.05).Conclusion The less decrease of the immune function was seen in terms of NP chemotherapy compared with DP of patients with advanced non-small cell lung cancer.Therefore,NP chemotherapy is proved to the better chemotherapy regimens.
