One case report and analysis of patient with renal immunoglobulin light and heavy chain deposited disease
10.3760/cma.j.issn.1008-6315.2014.10.020
- VernacularTitle:肾脏轻链-重链沉积病一例并文献复习
- Author:
Guang YIN
;
Yan WU
;
Caihong ZENG
;
Huiping CHEN
;
Zhihong LIU
- Publication Type:Journal Article
- Keywords:
Light and heavy chain deposited disease;
κ light chain;
IgG1;
Monoclonal immunoglobulin deposition disease
- From:
Clinical Medicine of China
2014;30(10):1063-1066
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report 1 case with renal immunoglobulin light and heavy chain deposited disease (IgG-κ light chain and γ1 heavy chain).Methods The clinical manifestations,serum immunofixation electrophoresis,light and heavy chain abnormalities of blood and urine,bone marrow biopsy and renal biopsy data laboratory data were recorded and analyzed.Results A 63-year-old woman presented with massive proteinuria,microscopic hematuria,hypertension,anemia and serum IgG-κ light chain.Bone marrow aspirate revealed 4％ plasma cells.Renal biopsy revealed nodular glomerulopathy with congo red staining-negative.Immunofluorescence showed that κ light chain and IgG1 (γ1 heavy chain) were deposited along the glomerular basement membranes (GBM) and tubular basement membranes (TBM).Electron-microscopy revealed electrondense deposits that delineate the outer aspect of TBM and endothelial aspect of GBM.Conclusion The diagnosis of renal immunoglobulin light and heavy chain deposited disease (IgG-κ light chain and γ1 heavy chain) should be addressed combine with clinical and is pathology,especially with immune pathological examination.
