Reversible posterior leukoencephalopathy syndrome after acute lymphoblastic leukemia chemotherapy: a case report and review of literature

VernacularTitle:急性淋巴细胞白血病化疗后可逆性后部白质脑病综合征一例并文献复习
Author: Zhengjiang TIAN ; Jishi WANG ; Hongqian ZHU
Publication Type:Journal Article
Keywords: Acute lymphoblastic leukemia; Chemotherapy; Reversible posterior leukoencephalopathy syndrome
From: Journal of Leukemia & Lymphoma 2015;24(3):181-183
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical manifestations,treatment and prognosis of reversible posterior leukoencephalopathy syndrome (RPLS) after acute lymphoblastic leukemia chemotherapy.Methods The clinical and imaging data of one case with acute lymphoblastic leukemia were analyzed and literatures were reviewed.Results The main clinical presentation of the patient included abdominal distension,repeated fever with fatigue.Depend on the results of the blood routine test and bone marrow relative examinations,the patient was diagnosed as acute lymphoblastic leukemia pro-B cell high risk group.After the induction therapy and consolidation chemotherapy,hypertension and neurological symptoms were appeared.Combined with the imaging examination,it was diagnosed as RPLS.Recieved active treatment,the patient recovered completely,and the imaging test was improved rapidly.Conclusion The causes of RPLS are variety,and its clinical manifestations and imaging test are non-specific.RPLS has a favorable prognosis.The correct diagnosis and treatment are the key points.