Effect of cytomegalovirus infection on infant weight growth and correlation between the weight growth and copies number of the virus
10.3760/cma.j.issn.1008-6315.2014.10.002
- VernacularTitle:巨细胞病毒感染对婴幼儿体质量影响及与病毒拷贝数相关性分析
- Author:
Qianqian LI
;
Jun WANG
;
Fang LIU
;
Fangfang ZHANG
;
Tingting HAN
;
Yan XU
- Publication Type:Journal Article
- Keywords:
Cytomegalovirus;
Infection;
Body quality;
Children
- From:
Clinical Medicine of China
2014;30(10):1012-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cytomegalovirus(HCMV) infection on infant bodyquality growth,and analysis of the correlation between children of all ages body-quality growth rate and copy number of the virus.Methods One hundred and sixty-eight children with HCMV infection were enrolled in the current study who were hospitalized from Oct.2012 to Oct 2013 in the Affiliated Hospital of Xuzhou Medical College.Children's urine HCMV-DNA copy number was measured by TaqMan probe fluorescence quantitative PCR.The retrospective study was conducted to compare the HCMV infection in children with weight-for-age and normal children.The correlation between children with body-quality growth rate and copy number of the virus was analyzed.Results All 168 urine specimens were positive regarding HCMV-DNA.The age of all distribution was from 1 month to 3 years.There was a negative correlation between the increase body weigh and the copies of virus of children with 3-6 months (r =-0.774,P ＜ 0.01).Conclusion The growth and development of children with HCMV at age before 6 months were slower than Children with the same age.The growth of cytomegalovirus infection increase gradually speeding when they were over 6 months and it was approaching to that same age when they are 2 years old.The growth rate is lower than that of normal children when HCMV children were before 1 years old.The correlation of body-quality growth rate and the number of copies of the virus was negative,especially from 3 months to 6 months.
