Prognostic values of tumor-stroma ratio and tumor-infiltrating lymphocytes in stagesⅡandⅢcolorectal cancer
10.3969/j.issn.1000-8179.20142129
- VernacularTitle:肿瘤间质比及肿瘤浸润性淋巴细胞对晚期结直肠癌的预后价值
- Author:
Xi ZHANG
;
Bailai HU
;
Zhen LV
;
Guangzhen MA
;
Lirong CHEN
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
TSR;
TIL;
prognosis
- From:
Chinese Journal of Clinical Oncology
2015;46(4):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic values of tumor–stroma ratio and tumor-infiltrating lymphocytes in colorec-tal cancer. Methods:A total of 218 stageⅡorⅢprimary colorectal cancer patients were analyzed for the tumor–stroma ratio (TSR) and tumor-infiltrating lymphocytes (TIL) by using HE stained histological sections. The relationship between TSR and clinicopatholog-ic variables and the difference in clinical outcomes of different groups were also analyzed. Results:Overall survival rates for the stro-ma-low group were significantly higher than the stroma-high group in stagesⅡandⅢcolorectal cancer (P＜0.05). However, the differ-ences in TSR were not correlated with clinicopathologic features such as gender and age (P>0.05). Overall survival rates of patients with high TIL were significantly higher than patients with low TIL (P＜0.05). Patients with high TIL had notable better prognosis than patients with low TIL (P＜0.05) in the stroma-low group. Conclusion:TSR and TIL are independent prognostic factors for stagesⅡandⅢcolorectal cancer. The combined estimates of TSR and TIL in routine pathology diagnoses may provide more evidence to predict the prognosis of stagesⅡandⅢcolorectal cancer.
