Research progress in targeted immunotherapy combined with ra-diotherapy for stageⅢ/Ⅳmelanomas
10.3969/j.issn.1000-8179.20141968
- VernacularTitle:靶向免疫治疗联合放射治疗在晚期黑色素瘤中的研究进展
- Author:
Xiaomei LUO
;
Jibing CHEN
;
Lizhi NIU
- Publication Type:Journal Article
- Keywords:
targeted immunotherapy;
radiotherapy;
melanoma;
therapeutic alliances
- From:
Chinese Journal of Clinical Oncology
2015;46(4):255-258
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma is the most aggressive and lethal malignant tumor in skin cancers. Operation resection is used to treat stageⅠ/Ⅱmelanomas, but traditional operation, chemotherapy, and radiotherapy inflicts adverse effects on late-stage melanomas. StageⅢ/Ⅳmelanomas are some of the most ineffectively treated tumors with poor prognosis. As a cancer treatment, targeted immunotherapy in-hibits negative regulatory factors and enhances systemic anti-tumor immune effects. Radiotherapy not only kills tumor cells, but also en-hances systemic immune responses. Recent studies showed that targeted immunotherapy combined with radiotherapy can promote con-trol on local and distant tumors and prolong overall survival. The synergistic effects of these two therapies are superior to a single thera-py. This review summarized the progress on these research fields.
