Beta-tricalcium phosphate combined with organic polymer as bone scaffolds:scaffold preparation and application
10.3969/j.issn.2095-4344.2014.43.025
- VernacularTitle:β-磷酸三钙复合有机高分子聚合物骨支架材料：制备及应用中的问题
- Author:
Shuo YE
;
Ping ZHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2014;(43):7033-7038
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Studies have shown that theβ-tricalcium phosphate can be combined with other macromolecular compounds to improve the mechanical strength and histocompatibility, meeting the requirements of clinical application. ＜br> OBJECTIVE:To evaluate the selection and preparation methods of composite scaffold in bone tissue engineering, and to describe the problems we are facing. ＜br> METHODS:The first author retrieved PubMed, Google Scholar, CNKI, Wanfang, and VIP databases by computer using the keywords of“β-tricalcium phosphate,β-TCP, PLGA, PLA, scaffold, prepare”in English and Chinese, respectively. ＜br> RESULTS AND CONCLUSION:β-tricalcium phosphate combined with polylactic acid-glycolic acid/polylactic acid as bone tissue engineering scaffolds has achieved a great progress. At present, the organic polymer composite scaffolds can be prepared by microsphere sintering, fiber bonding, solvent casting/particulate leaching, emulsification/freeze drying technology, gas foaming method, phase separation technology, rapid prototyping technology and electrostatic spinning method.β-tricalcium phosphate composite scaffolds with polylactic acid-glycolic acid/polylactic acid can be customizable so as to meet different requirements for bone tissue engineering, which can improve the porosity, mechanical properties and biodegradation by improving fabrication techniques and processings, ratio of raw materials and fil er proportion.
