Clinical analysis of cytogenetic features in acute myeloid leukemia and its relationship with early responses after induction therapy
10.3760/cma.j.issn.1009-9921.2013.04.004
- VernacularTitle:急性髓系白血病细胞遗传学特征与诱导治疗反应的相关性分析
- Author:
Yinghui XU
;
Jiuwei CUI
;
Wei LI
;
Xiuli HAN
;
Tingting LIANG
;
Guanjun WANG
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,acute;
Cytogenetics;
Karyotyping;
Complete remission rate
- From:
Journal of Leukemia & Lymphoma
2013;22(4):206-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cytogenetic features of acute myeloid leukemia (AML) and analyze the association with cytogenetic features and early responses after induction therapy.Methods The karyotypes of 395 patients who had been newly diagnosed with AML were analyzed.These patients were divided into three groups (low-risk,intermediate-risk and high-risk),according to the AML NCCN guidelines.The incidence of different karyotypes in these three groups and the complete remission (CR) rate after the first cycle of induction therapy were analyzed.Results The incidence rates of karyotypes in high-risk,intermediate-risk and low-risk groups were 50.56 ％ (180/356),39.89 ％ (142/356),9.55 ％ (34/356),respectively.All patients with t(15;17) who completed induction therapy reached CR.There was significant difference in the CR rates of t(8;21) groups with or without additional karyotypes [92.00 ％(23/25) vs 50.00 ％(11/22)] (x2 =10.317,P =0.001).There was no significant difference in the CR rates between normal and-Y karyotype group [61.90 ％ (39/63) vs 58.82 ％ (10/17)] (x2 =0.054,P =0.817).Complex cytogenetics ascribed to the low-risk group,of which monosomal karyotype was common,nine of ten patients with monosomal karyotype were associated with an inferior CR rate.Conclusion The cytogenetic features of AML are different from previous reports by other centers.The cytogenetic features of AML patients not only influence the long-term survival,but also the CR rates of induction therapy.
