The Application of the Induced Pluripotent Stem Cells Disease Modeling
10.3969/j.issn.0253-9896.2014.04.031
- VernacularTitle:诱导性多能干细胞疾病模型的应用价值
- Author:
Xue BAI
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
induced pluripotent stem cells;
disease model;
pathological mechanism;
drug screening;
cell therapy
- From:
Tianjin Medical Journal
2014;(4):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Induced pluripotent stem cells (iPSC) technology play an important role in studying diseases in vitro. iPSC disease model was based on the iPSC technology, and has achieved important results in many diseases. For those spe-cific genetic diseases that are relatively easy to simulate, iPSC disease model is especially useful. This technology can direct-ly obtained required material from patients, which is free from ethical constraints and rich in cell sources . iPSC disease model as widely used in studying disease mechanism, drug screening, safety inspection, cell therapy, and so on. It is expect-ed to be used in gene correction, gene repair and to obtain the required target cells for the treatment. Cells modification caused by reprogram, lacking of optimum experimental scheme for cell differentiation and difference in genetic backgrounde limit the application of iPSC disease model. More advanced nonintegrated programming technology, improvement of culture conditions, stricter quality control and setting up the standard for iPSC disease model will help to solve these problems.
