Clinical significance of immature reticulocyte fraction in patients with acute myeloid leukemia following consolidation chemotherapy with high-dose cytarabine
10.3760/cma.j.issn.1009-9921.2013.05.011
- VernacularTitle:急性髓系白血病患者巩固化疗过程中未成熟网织红细胞分数检测的临床意义
- Author:
Qiong CHEN
;
Yimin CHENG
;
Qi ZHU
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,acute;
Drug therapy;
Cytarabine;
Immature reticulocyte fraction
- From:
Journal of Leukemia & Lymphoma
2013;22(5):291-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of peripheral blood parameters including immature reticulocyte fraction (IRF) in monitoring the hematopoietic recovery of patients with acute myeloid leukemia aftcr receiving consolidation chemotherapy with high dose cytarabine (HDAC).Methods The peripheral blood parameters,including absolute neutrophil (ANC) and platelet (Plt) counts as well as IRF,were measured by Sysmex XE-2100 automated hematology analyzer before and after consolidation chemotherapy with HDAC in 30 patients with acute myeloid leukemia.These peripheral blood parameters were further statistically analyzed and compared.Results Following consolidation chemotherapy,the median time to recovery for ANC,Plt and IRF was (9.2±2.5) days,(11.3±3.7) days and (5.0±2.6) days,respectively.In comparison with ANC and Plt recovery,IRF showed significantly early recovery (P ＜ 0.05).Additionally,ANC raised preceding Plt recovery (P ＜ 0.05).However,the median recovery time of ANC,Plt and IRF showed little difference among these patients further subgrouped according to FAB and risk based classification (P ＞ 0.05).Conclusion IRF is an early indicator for the hematopoietic recovery of patients with acute myeloid leukemia following consolidation chemotherapy with HDAC,which could provide important clinical information to evaluate therapeutic efficacy.
