Expressions of Bcl-2 and Caspase-3 in Ulcerative Colitis
10.3969/j.issn.0253-9896.2013.09.001
- VernacularTitle:Bcl-2与Caspase-3在溃疡性结肠炎中的表达与意义*
- Author:
Qian WANG
;
Yonghui LV
;
Limei ZHOU
;
Wenjian CHEN
;
Guiying JIANG
;
Yi JIANG
- Publication Type:Journal Article
- Keywords:
caspase 3;
bcl-2-associated X protein;
colitis,ulcerative;
epithelial cells;
intestinal mucosa
- From:
Tianjin Medical Journal
2013;(9):849-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the expressions of Bcl-2 and Caspase-3 in intestinal epithe-lial and inflammatory cells of lamina propria and the staging and pathogenesis of ulcerative colitis (UC). Methods The pathomorphological changes of 25 samples of UC in the active phase and remission phase and 25 samples of control were ob-served under microscope. The expressions of Bcl-2 and Caspase-3 were detected by immunohistochemistry SP method. The correlations between expressions of Bcl-2, Caspase-3 and UC staging were analyzed. Results There were no significant dif-ferences in expressions of Bcl-2 and Caspase-3 in intestinal epithelial cells between three groups (P>0.05). The expression of Bcl-2 in inflammatory cells of lamina propria was significantly higher in active UC group than that of normal control group (P＜0.05), no significant difference between UC remission group and normal control group (P>0.05). There was a higher positive expression of Caspase-3 in inflammatory cells of lamina propria in UC remission group. There was correlation be-tween Bcl-2, Caspase-3 and UC staging (r=0.371 and 0.4453 respectively). Conclusion The expression levels of Bcl-2 and Caspase-3 were related with pathogenesis of UC. The detection of expression levels of Bcl-2 and Caspase-3 has a cer-tain application value in UC staging.
