Expression and Clinical Significance of TFF3 and SDF-1 Proteins in Papillary Thyroid Carcinoma
10.3969/j.issn.0253-9896.2013.09.004
- VernacularTitle:TFF3和SDF-1在甲状腺乳头状癌中的表达及临床意义*
- Author:
Jingfang WU
;
Jing HUANG
;
Gang XUE
;
Jing ZHANG
;
Wenjing ZHANG
;
Xiaojun ZHANG
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms;
carcinoma,papillary;
immunohistochemistry;
trefoil factor 3;
stromal cell derived fac-tor 1
- From:
Tianjin Medical Journal
2013;(9):859-862
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of trefoil factor 3 (TFF3) and stromal cell de-rived factor-1 (SDF-1) in papillary thyroid carcinoma (PTC) and adjacent tissues, and to provide the basis for clinical diagno-sis and prognosis evaluation. Methods The expressions of TFF3 and SDF-1 proteins in PTC and adjacent tissues were de-tected by immunohistochemical SP method. The relationship between expressions of TFF3, SDF-1 and clinicopathological features was analyzed. Results (1) The positive rate and the expression level of TFF3 protein were significantly higher in PTC than those in adjacent tissues, which were higher in patients with lymph node metastasis than those in patients without lymph nodes metastasis, and were higher in PTC patients of stageⅢ/Ⅳthan those in patients of stageⅠ/Ⅱ(P＜0.05). The strong positive rate of TFF3 protein in stageⅢ/Ⅳof PTC patients was higher than that in stageⅠ/Ⅱ(P＜0.01). (2) The posi-tive rate and the expression level of SDF-1 protein were significantly higher in PTC than those in adjacent tissues, which were higher in patients with lymph node metastasis than those in patients without lymph nodes metastasis, and were higher in PTC patients of stageⅢ/Ⅳthan those in patients of stageⅠ/Ⅱ, and were significantly higher in patients over 45 years old than those of patients≤45 years old (P＜0.05). (3) There was a positive correlation between expression levels of TFF3 and SDF-1 proteins in PTC (r=0.266,P＜0.05). Conclusion The higher expressions of TFF3 and SDF-1 in PTC were closely correlated with carcinogenesis and progression, which may play a significant value in judging the malignant degree and pro-gression of PTC.
