Observation on Epigallocatechin Gallate Treating the Bladder Tumor Induced by N-methyl-N-nitrosourea in Rats

VernacularTitle:茶多酚治疗N-甲基亚硝基脲诱发膀胱肿瘤的实验研究*
Author: Guoqing LIANG ; Chunlei CHEN ; Weijie CHEN ; Xiaofeng ZHANG
Publication Type:Journal Article
Keywords: urinary bladder neoplasms; tea; phenols; methylnitrosourea; models,animal; rats,Wistar; tea polyphenol
From: Tianjin Medical Journal 2013;(9):898-900
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic effect of epigallocatechin gallate (EGCG) on the bladder neo-plasm induced by N-methyl-N-nitrosourea (MNU) in Wistar rats. Methods Seventy-two female rats were randomly divid-ed into two groups, treatment group and control group. The rat model of bladder tumor was established by intravesical instilla-tion of MNU (2mL/time, once every two weeks) inside bladder. Rats in treatment group were given EGCG (2 mL/time, once/day), and control group were given the same volume of distilled water. Six rats were executed respectively at the 3rd, 5th, 7th, 9th, 11th and 13th week, and the bladder histopathological changes were studied in two groups. Results The untypical hyper-plasia was observed after 5 weeks. The bladder neoplasm was observed at the 11th week in control group. The bladder neo-plasm was not found in treatment group. There was a significantly lower pathological score in treatment group than that of control group except for the first two weeks (P＜0.05). Conclusion EGCG is effective for treatment of the bladder neo-plasm induced by MNU.