Impacts of Different Doses of Alcohol on Rat Endothelial Microparticles

VernacularTitle:不同剂量白酒对大鼠内皮细胞微颗粒水平的影响*
Author: Yazhuo ZHANG ; Man ZHENG ; Jiuying CAI
Publication Type:Journal Article
Keywords: ethanol; endothelium,vascular; endothelial microparticles; flow cytometry; rat,Sprague-Dawley
From: Tianjin Medical Journal 2013;(9):904-905
CountryChina
Language:Chinese
Abstract: Objective To discuss the impacts of different doses of alcohol on the level of microparticles (EMPs) of rat endothelial cells. Methods Sixty male SD rats were randomly allocated into four groups:high dose group (group A), me-dium dose group (group B), low dose group (group C) and the blank contrast group (group D). There were15 rats in each group. Rats were fed alcohol for 8 weeks. Flow cytometer was used to measure the level of circulating CD31+/CD42-EMPs in four groups, and which was compared with the alcohol dosage. Results Compared with group D, the level of circulating EMPs was significantly increased in group A and B (P＜0.05). There was no significant change in the level of circulating EMPs in group C (P>0.05). Conclusion The moderate and high doses of alcohol are harmful to the function of vascular en-dothelial cells in rats, which show a significant dose-effect relationship. The low dose of alcohol shows no effect on the func-tion of vascular endothelial cells in rats. The protective effect of alcohol needs further investigation.