The Expression and Clinical Significance of HBD-2 in Gastric Mucosa of H. pylori Associated Gastric MALT Lymphoma
10.3969/j.issn.0253-9896.2013.08.002
- VernacularTitle:H. pylori相关胃MALT淋巴瘤患者胃黏膜中β防御素-2的表达研究
- Author:
Haoyu ZHAI
;
Zhiguang ZHANG
;
Kui JIANG
;
Man LI
- Publication Type:Journal Article
- Keywords:
lymphoma,B-cell,marginal zone;
helicobacter pylori;
beta-defensins;
stomach neoplasms;
gastric MALT lymphoma
- From:
Tianjin Medical Journal
2013;(8):756-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of humanβ-defensin 2 (HBD-2) in gastric mucosa of Helico-bacter pylori (H. pylori) associated gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and the role of HBD-2 in gastric MALT lymphoma. Methods Forty gastric mucosa specimens from patients with H. pylori associated gastric MALT lymphoma were collected. And 36 gastric mucosa specimens from chronic superficial gastritis without H. pylori infection were included as control group. The expression of HBD-2 was detected by immunohistochemistry staining. Results The ex-pression of HBD-2 was significantly higher in H. pylori associated gastric MALT lymphoma than that of control group. (P＜0.01). The expression of HBD-2 was significantly decreased after the eradication of H. pylori (P＜0.01). The expression of HBD-2 was significantly higher in H. pylori associated gastric MALT lymphoma than that of lymphoma cells (P＜0.01). There was no expression of HBD-2 in lymphoma cells. Conclusion HBD-2 is possibly involved in the pathogenesis of H. pylori associated gastric MALT lymphoma. But whether it has anti-tumor effect is not clear.
