Comparison Research on the Blood Loss after Total Knee Arthroplasty between Tranexamic Acid Single Dose Intra-articular Injection of Tranexamic Acid and Autologous Blood Transfusion Drainage Systems
10.3969/j.issn.0253-9896.2013.08.011
- VernacularTitle:氨甲环酸关节腔内注射和自体血回吸收器对TKA术后失血的影响
- Author:
Lei WANG
;
Jun LIU
;
Bo SHI
;
Yunbo SUN
;
Yu ZHANG
;
Huiwen ZHAO
;
Zhenhui SUN
- Publication Type:Journal Article
- Keywords:
knee prosthesis;
arthroplasty,replacement,knee;
tranexamic acid;
blood transfusion,autologous;
blood loss,surgical
- From:
Tianjin Medical Journal
2013;(8):779-781
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficiency of intra-articular injection of tranexamic acid (TXA) and autolo-gous transfusion drain on the blood loss after total knee arthroplasty (TKA). Methods A total of 124 patients (124 knees) with varus knee osteoarthritis, who were performed TKA,were retrospectively analyzed. Patients included 24 males and 100 females. The mean age was(65.03±6.84)years. Due to the blood loss control method, patients were divided into two groups including TXA application group (test group, n=49) and autologous transfusion drain group (control group, n=75). The data of blood routine examination, blood loss and blood transfusion after TKA were analyzed. Results The blood transfusion rates were 10.20%(5/49) in test group and 17.33%(13/75) in control group 7 days after TKA surgery. There was no signifi-cant difference between two groups (P>0.05). There were significant differences in red blood cell (RBC), hemoglobin (Hb) and haematocrit (HCT) between groups and effects of interaction in the two groups (P＜0.01). There were significantly higher values of RBC, Hb and HCT at 1, 3 and 7 days after surgery in test group than those of control group (P＜0.05).The total blood loss 1 and 3 days after TKA was significantly lower in test group than that of control group (P＜0.05). There was no sig-nificant difference in the blood loss 7 days after surgery between two groups (P>0.05). Conclusion The single dose intra-articular injection of tranexamic acid is a safe and effective procedure for hemostasis after TKA.
