Significance of C-erbB-2 Oncoprotein as a Pognostic Predictor for Human Breast Cancer.
- Author:
Ki Jae PARK
1
;
Se Heon CHO
;
Young Hoon KIM
;
Ghap Joong JUNG
;
Sang Soon KIM
;
Sook Hee HONG
Author Information
1. Departments of Surgery, Dong-A University Graduate School, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
C-erbB-2;
Breast cancer
- MeSH:
Breast Neoplasms*;
Breast*;
Humans*;
Lymph Nodes;
Neoplasm Metastasis
- From:Journal of the Korean Surgical Society
1998;55(1):44-52
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Immunohistochemical staining for the C-erbB-2 oncoprotein was performed on sections from paraffin- embedded tissue blocks of 96 primary breast-cancer patients who were operated on our hospital, in order to evaluate its significance as a prognostic factor in human breast cancer. We investigated the correlation between the traditional prognostic factors - patient age, primary tumor size, axillary lymph-node metastasis, pathological grade, and hormonal receptors(ER & PR) - and C-erbB-2 oncoprotein overexpression. The overall rate of positive staining of the C-erbB-2 oncoprotein was 37.5% (36/96). Statistically, the C-erbB-2 positive staining was not correlated with patient age, primary tumor size, axillary lymph node involvement, or hormonal receptors. However a high pathologic grade appeared to be statistically correlated with C-erbB-2 oncoprotein overexpression(p=0.010). In conclusion, the C-erbB-2 oncoprotein appears to have prognostic significance in human breast cancer.
