Post-transplant lymphoproliferative disorders following renal transplantation: 4 cases report and literatures review

VernacularTitle:肾移植后淋巴组织增生性疾病四例并文献复习
Author: Liang REN ; Xiaopeng HU ; Hang YIN ; Wei WANG ; Hang LIU ; Xiaodong ZHANG
Publication Type:Journal Article
Keywords: Renal transplant; Post-transplant lymphoproliferative disorders; Diagnosis; Treatment
From: Journal of Leukemia & Lymphoma 2013;22(7):444-447
CountryChina
Language:Chinese
Abstract: Objective To study the clinicopathologic features of post-transplant lymphoproliferative disorders (PTLD) following renal transplantation.Methods Four cases of PTLD following renal transplantation were studied and relevant literatures were reviewed.Results All the 4 cases had received 3-drug-immunosuppression after transplantation.The duration between renal transplantation and diagnosis of PTLD was 5-112 months,averagely 34 months.The patients were suffered from infective monocytic hyperplasialike PTLD,plasmacytic hyperplasialike PTLD,polymorphic PTLD and monomorphic PTLD respectively in morphology and had no specific symptoms.All the patients received therapy with dosage reduction of immunosuppressants and some received rituximab or chemotherapy.The case of monomorphic PTLD died in a short time after diagnosis.Conclusion PTLD is a lymphoproliferative disease with distinctive morphologic and clinical characteristics.The main treatments include the dosage reduction of immunosuppressive agents,biotherapy and chemotherapy.The prognosis of monomorphic PTLD is poor.