Prognostic evaluation of clinical scoring systems for patients undergoing resection of colorectal cancer liver metastases
10.3760/cma.j.issn.1007-8118.2015.06.007
- VernacularTitle:结直肠癌肝转移患者临床风险评分体系的预后评价
- Author:
Xiaoluan YAN
;
Kun WANG
;
Quan BAO
;
Yi SUN
;
Hongwei WANG
;
Kemin JIN
;
Baocai XING
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Liver metastases;
Hepatectomy;
Clinic risk score;
Prognostic evaluation
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(6):388-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the risk factors associated with overall survival (OS) for patients undergoing partial hepatectomy for colorectal liver metastases,and to assess the predictive values of five published scoring systems in an independent patient cohort for the purpose of external validation.Methods The clinical,pathologic,and complete follow-up data were prospectively collected from 303 consecutive patients who underwent primary hepatic resection for colorectal liver metastases at the Beijing Cancer Hospital from January 2000 to Aug 2014.The predictive values of the Nordlinger score,the Memorial Sloan-Kettering Cancer Center (MSKCC) score,the Iwatsuki score,the Basingstoke index,and the Konopke scoring system were assessed in this patient set.The clinical and pathologic parameters were further analyzed using univariate and multivariate analyses.Results The 1-,3-and 5-year overall survival were 89.2％,50.8％ and 38.6％,respectively.The median survival time was 37 months.Two risk factors were found to be independent predictors of poor overall survival:the N stage of the primary tumor,and a carcinoembyonic antigen level ＞ 30 μg/L.The MSKCC score had the best independent predictive power for survival when compared with the other 4 prognostic systems (C-index:0.903).Conclusion In our patient cohort,the MSKCC score was the best staging system in predicting survival.
