Genetic basis and risk stratication of multiple myeloma

VernacularTitle:多发性骨髓瘤的遗传学基础与危险分层
Author: Yuan JIAN ; Wenming CHEN
Publication Type:Journal Article
Keywords: Multiple myeloma; Genetics; Risk stratication
From: Journal of Leukemia & Lymphoma 2013;22(1):32-34
CountryChina
Language:Chinese
Abstract: Multiple myeloma (MM) is a heterogeneous disease.The prognosis of MM varied a lot among different patients.One of the main basis of risk stratification is genetic abnormality,which including the number or structure anomaly of chromosomes,genetic aberrations,signaling pathway disorders and epigenetic changes.The risk stratification is being revised with the development of FISH,gene-expression profiling and next-generation sequencing.These combined approaches would hopefully transform the current one-for-all care into a more tailored,individual therapeutic strategy for MM patients and would finally improve their quality of lives.