The Expression of PIK3CA in Gastric Adenocarcinoma
10.3969/j.issn.0253-9896.2013.11.002
- VernacularTitle:PIK3CA在胃癌病变中表达的研究
- Author:
Feifei MA
;
Qingyu ZHANG
;
Tao WANG
;
Chunsheng KANG
;
Rong XU
;
Fengying CAI
;
Xiaomei SONG
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
adenocarcinoma;
1-phosphatidylinositol 3-kinase;
protein-serine-threonine kinas-es;
ki-67 antigen;
immunohistochemistry;
tissue microarrays
- From:
Tianjin Medical Journal
2013;(11):1045-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between phosphatidylinositol 3-kinase catalytic subunit α(PIK3CA) expression and the incidence and different pathological grade of gastric cancer, and the mechanism thereof. Meth-ods The expressions of PIK3CA, serine/threonine protein kinase (pAkt) and cell proliferation associated nuclear antigen (ki-67) in gastric carcinoma and adjacent tissues and normal gastric mucosa were detected by immunohistochemical method. The relationship between expressions of PIK3CA, pAkt and ki-67 and tumorigenesis was analyzed. The expressions of PIK3CA, pAkt and ki-67 in different pathological conditions of gastric tissues were analyzed. The relationship between tu-mor pathologic classification and differentiation were analyzed too. Results There were significantly higher expressions of PIK3CA, pAkt and ki-67 in gastric cancer (P＜0.05), which were the highest in the poorly differentiated gastric adenocarci-noma (P＜0.05). There were a positive correlation between expressions of PIK3CA, pAkt and ki-67 and different pathologi-cal levels of gastric carcinoma and adjacent tissues and normal gastric tissues (P＜0.05). Conclusion PIK3CA may be the initiating factor of PI3K/Akt signaling pathway, which induced phosphorylation of Akt and activation PI3K/Akt signaling pathway, promoting the proliferation, invasion and metastasis of gastric adenocarcinoma.
