The Expression and Clinical Significance of DKK1, SFRP4 and Wnt1 in Cervical Squamous Cell Carcinoma
10.3969/j.issn.0253-9896.2013.11.009
- VernacularTitle:DKK1、SFRP4和Wnt1在宫颈鳞癌中的表达及意义
- Author:
Anli HOU
;
Xiufen LI
;
Yali ZHANG
;
Dongrui YANG
;
Xiaoxia SU
- Publication Type:Journal Article
- Keywords:
uterine cervical neoplasms;
carcinoma,squamous cell;
Wnt1 protein;
immunohistochemistry;
dickkopf 1;
SFRP4
- From:
Tianjin Medical Journal
2013;(11):1070-1072
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of DKK1,SFRP4 and Wnt1 in cervical squamous cell carcino-ma(SCC), and the clinical significance thereof. Methods There were 76 samples of cervical squamous cell carcinoma were included in SCC group and 36 benign uterine resection specimens were control group (NC). The immunohistochemical meth-od was applied to detect the expressions of DKK1,SFRP4 and Wnt1 in two groups. Results The expression of DKK1 was significantly lower in SCC group than that in NC group (P＜0.05). The expression levels of SFRP4 and Wnt1 were significant-ly higher in SCC group than those of NC group (P＜0.05). There were significant differences in the expressions of DKK1, SFRP4 and Wnt1 between samples of different clinical staging, differentiation, sizes of tumor and lymph node metastasis (P＜0.05). The expression of DKK1 was negatively correlated with SFRP4 and Wnt1 in SCC group (P＜0.05). The expression of SFRP4 was positively correlated with Wnt1 in SCC group (P＜0.05). Conclusion The roles of SFRP4 and Wnt1 are syn-ergistic interactions in the development of SCC. DKK1 is an inhibiting factor of SCC.
